Drug interactions
Chloral hydrate + Lormetazepam
Severity: Moderate
Chloral hydrate and Lormetazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lormetazepam is a benzodiazepine hypnotic, and use with chloral hydrate increases sedation and psychomotor impairment. The risk of falls and respiratory depression is higher in elderly or debilitated patients.
What this interaction means in plain words
Chloral hydrate and Lormetazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through GABA-A enhancement by both drugs.
What to do
Avoid using both together when possible; if needed, reduce doses and monitor sedation and respiratory status.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloral hydrate
- Calcium / magnesium / potassium / sodium oxybates + Chloral hydrate Contraindicated
- Chloral hydrate + Sodium oxybate Contraindicated
- Alfentanil + Chloral hydrate Major
- Alprazolam + Chloral hydrate Major
- Amobarbital + Chloral hydrate Major
- Belladonna and opium + Chloral hydrate Major
Frequently asked questions
Can I take Chloral hydrate with Lormetazepam?
MediHelp rates the interaction as moderate. Chloral hydrate and Lormetazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lormetazepam is a benzodiazepine hypnotic, and use with chloral hydrate increases sedation and psychomotor impairment. The risk of falls and respiratory depression is higher in elderly or debilitated patients.
How serious is the interaction between Chloral hydrate and Lormetazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using both together when possible; if needed, reduce doses and monitor sedation and respiratory status.
What other medicines interact with Chloral hydrate?
MediHelp also lists interactions of Chloral hydrate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Chloral hydrate page.
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