Drug interactions
Chloral hydrate + Meprobamate
Severity: Moderate
Chloral hydrate and Meprobamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meprobamate is a carbamate anxiolytic-sedative, and combined use with chloral hydrate results in additive CNS depression. Excess drowsiness, impaired coordination and respiratory depression may occur, particularly in overdose.
What this interaction means in plain words
Chloral hydrate and Meprobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from two sedative-hypnotic agents acting on GABAergic pathways.
What to do
Avoid concurrent use where possible; if both are required, use the lowest doses and monitor sedation and respiration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloral hydrate
- Calcium / magnesium / potassium / sodium oxybates + Chloral hydrate Contraindicated
- Chloral hydrate + Sodium oxybate Contraindicated
- Alfentanil + Chloral hydrate Major
- Alprazolam + Chloral hydrate Major
- Amobarbital + Chloral hydrate Major
- Belladonna and opium + Chloral hydrate Major
Frequently asked questions
Can I take Chloral hydrate with Meprobamate?
MediHelp rates the interaction as moderate. Chloral hydrate and Meprobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meprobamate is a carbamate anxiolytic-sedative, and combined use with chloral hydrate results in additive CNS depression. Excess drowsiness, impaired coordination and respiratory depression may occur, particularly in overdose.
How serious is the interaction between Chloral hydrate and Meprobamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible; if both are required, use the lowest doses and monitor sedation and respiration.
What other medicines interact with Chloral hydrate?
MediHelp also lists interactions of Chloral hydrate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Chloral hydrate page.
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