Drug interactions
Chloral hydrate + Metoclopramide intranasal
Severity: Moderate
Chloral hydrate and Metoclopramide intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide can cause CNS effects such as drowsiness, extrapyramidal symptoms and confusion, which may be compounded by chloral hydrate sedation. The clinical significance is based mainly on additive effects.
What this interaction means in plain words
Chloral hydrate and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects; no specific pharmacokinetic mechanism established.
What to do
Avoid combining where an alternative exists. If both are required, monitor for excessive sedation and movement disorders and warn about driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloral hydrate
- Calcium / magnesium / potassium / sodium oxybates + Chloral hydrate Contraindicated
- Chloral hydrate + Sodium oxybate Contraindicated
- Alfentanil + Chloral hydrate Major
- Alprazolam + Chloral hydrate Major
- Amobarbital + Chloral hydrate Major
- Belladonna and opium + Chloral hydrate Major
Frequently asked questions
Can I take Chloral hydrate with Metoclopramide intranasal?
MediHelp rates the interaction as moderate. Chloral hydrate and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide can cause CNS effects such as drowsiness, extrapyramidal symptoms and confusion, which may be compounded by chloral hydrate sedation. The clinical significance is based mainly on additive effects.
How serious is the interaction between Chloral hydrate and Metoclopramide intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where an alternative exists. If both are required, monitor for excessive sedation and movement disorders and warn about driving.
What other medicines interact with Chloral hydrate?
MediHelp also lists interactions of Chloral hydrate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Chloral hydrate page.
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