Drug interactions
Chloral hydrate + Moxonidine
Severity: Moderate
Chloral hydrate and Moxonidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness, so combined use may deepen sedation and impair psychomotor performance. Moxonidine may also lower blood pressure, which can add to dizziness.
What this interaction means in plain words
Chloral hydrate and Moxonidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects from GABAergic sedation (chloral hydrate metabolite trichloroethanol) and central alpha-2/imidazoline agonism.
What to do
Monitor sedation and blood pressure, start with low doses, and advise patients to avoid driving or hazardous tasks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloral hydrate
- Calcium / magnesium / potassium / sodium oxybates + Chloral hydrate Contraindicated
- Chloral hydrate + Sodium oxybate Contraindicated
- Alfentanil + Chloral hydrate Major
- Alprazolam + Chloral hydrate Major
- Amobarbital + Chloral hydrate Major
- Belladonna and opium + Chloral hydrate Major
Frequently asked questions
Can I take Chloral hydrate with Moxonidine?
MediHelp rates the interaction as moderate. Chloral hydrate and Moxonidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause drowsiness, so combined use may deepen sedation and impair psychomotor performance. Moxonidine may also lower blood pressure, which can add to dizziness.
How serious is the interaction between Chloral hydrate and Moxonidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure, start with low doses, and advise patients to avoid driving or hazardous tasks.
What other medicines interact with Chloral hydrate?
MediHelp also lists interactions of Chloral hydrate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Chloral hydrate page.
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