Drug interactions
Chloral hydrate + Olanzapine
Severity: Moderate
Chloral hydrate and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine is a sedating atypical antipsychotic that adds to the CNS depressant effects of chloral hydrate. The combination can cause marked drowsiness, orthostatic hypotension and falls, especially in elderly patients.
What this interaction means in plain words
Chloral hydrate and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloral hydrate belongs to Central Nervous System; Olanzapine belongs to Central Nervous System.
Why it happens
Additive CNS depression and possible additive orthostatic hypotension.
What to do
Monitor sedation, blood pressure and respiration, and use reduced doses initially. Advise patients to avoid alcohol and rise slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloral hydrate
- Calcium / magnesium / potassium / sodium oxybates + Chloral hydrate Contraindicated
- Chloral hydrate + Sodium oxybate Contraindicated
- Alfentanil + Chloral hydrate Major
- Alprazolam + Chloral hydrate Major
- Amobarbital + Chloral hydrate Major
- Belladonna and opium + Chloral hydrate Major
Other interactions of Olanzapine
Frequently asked questions
Can I take Chloral hydrate with Olanzapine?
MediHelp rates the interaction as moderate. Chloral hydrate and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine is a sedating atypical antipsychotic that adds to the CNS depressant effects of chloral hydrate. The combination can cause marked drowsiness, orthostatic hypotension and falls, especially in elderly patients.
How serious is the interaction between Chloral hydrate and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, blood pressure and respiration, and use reduced doses initially. Advise patients to avoid alcohol and rise slowly.
What other medicines interact with Chloral hydrate?
MediHelp also lists interactions of Chloral hydrate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Chloral hydrate page.
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