Drug interactions
Chloral hydrate + Passion flower
Severity: Moderate
Chloral hydrate and Passion flower: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Passion flower has sedative properties and may enhance the CNS depression produced by chloral hydrate. Excess drowsiness and impaired alertness may result.
What this interaction means in plain words
Chloral hydrate and Passion flower can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive sedative effect, likely through GABAergic activity of passion flower constituents.
What to do
Advise patients to avoid herbal sedatives while taking chloral hydrate, or monitor sedation and avoid driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloral hydrate
- Calcium / magnesium / potassium / sodium oxybates + Chloral hydrate Contraindicated
- Chloral hydrate + Sodium oxybate Contraindicated
- Alfentanil + Chloral hydrate Major
- Alprazolam + Chloral hydrate Major
- Amobarbital + Chloral hydrate Major
- Belladonna and opium + Chloral hydrate Major
Frequently asked questions
Can I take Chloral hydrate with Passion flower?
MediHelp rates the interaction as moderate. Chloral hydrate and Passion flower can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Passion flower has sedative properties and may enhance the CNS depression produced by chloral hydrate. Excess drowsiness and impaired alertness may result.
How serious is the interaction between Chloral hydrate and Passion flower?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid herbal sedatives while taking chloral hydrate, or monitor sedation and avoid driving.
What other medicines interact with Chloral hydrate?
MediHelp also lists interactions of Chloral hydrate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Chloral hydrate page.
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