Drug interactions
Chloral hydrate + Sage
Severity: Minor
Chloral hydrate and Sage: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Some sage species have reported sedative or GABA-modulating activity, so they could add to the drowsiness produced by chloral hydrate. Clinical evidence is minimal.
What this interaction means in plain words
Chloral hydrate and Sage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive CNS depression via GABAergic effects of sage constituents; not well established.
What to do
Counsel patients to report excessive drowsiness and avoid concentrated sage supplements while taking chloral hydrate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chloral hydrate
- Calcium / magnesium / potassium / sodium oxybates + Chloral hydrate Contraindicated
- Chloral hydrate + Sodium oxybate Contraindicated
- Alfentanil + Chloral hydrate Major
- Alprazolam + Chloral hydrate Major
- Amobarbital + Chloral hydrate Major
- Belladonna and opium + Chloral hydrate Major
Frequently asked questions
Can I take Chloral hydrate with Sage?
MediHelp rates the interaction as minor. Chloral hydrate and Sage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Some sage species have reported sedative or GABA-modulating activity, so they could add to the drowsiness produced by chloral hydrate. Clinical evidence is minimal.
How serious is the interaction between Chloral hydrate and Sage?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report excessive drowsiness and avoid concentrated sage supplements while taking chloral hydrate.
What other medicines interact with Chloral hydrate?
MediHelp also lists interactions of Chloral hydrate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Chloral hydrate page.
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