Drug interactions
Chloral hydrate + Triazolam
Severity: Moderate
Chloral hydrate and Triazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents depress the central nervous system, so combined use can cause excessive sedation, impaired psychomotor performance and respiratory depression. Risk is greater in elderly patients and those with respiratory disease.
What this interaction means in plain words
Chloral hydrate and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABA-A receptor potentiation by trichloroethanol and triazolam.
What to do
Avoid combining where possible; if used together, start with reduced doses of each and monitor sedation and respiratory status. Counsel patients against driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloral hydrate
- Calcium / magnesium / potassium / sodium oxybates + Chloral hydrate Contraindicated
- Chloral hydrate + Sodium oxybate Contraindicated
- Alfentanil + Chloral hydrate Major
- Alprazolam + Chloral hydrate Major
- Amobarbital + Chloral hydrate Major
- Belladonna and opium + Chloral hydrate Major
Frequently asked questions
Can I take Chloral hydrate with Triazolam?
MediHelp rates the interaction as moderate. Chloral hydrate and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents depress the central nervous system, so combined use can cause excessive sedation, impaired psychomotor performance and respiratory depression. Risk is greater in elderly patients and those with respiratory disease.
How serious is the interaction between Chloral hydrate and Triazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; if used together, start with reduced doses of each and monitor sedation and respiratory status. Counsel patients against driving and alcohol.
What other medicines interact with Chloral hydrate?
MediHelp also lists interactions of Chloral hydrate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Chloral hydrate page.
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