Drug interactions
Chlorambucil + Dengue vaccine
Severity: Major
Chlorambucil and Dengue vaccine: major interaction.
Last updated Sources: Base de donnees publique des medicaments (France)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dengue vaccine is a live attenuated vaccine, and immunosuppression from chlorambucil can reduce the immune response and increase the risk of vaccine-related infection. Immunocompromised patients are generally not candidates for it.
What this interaction means in plain words
Chlorambucil and Dengue vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Immunosuppression impairs the response to a live attenuated vaccine and permits vaccine virus replication.
What to do
Avoid live dengue vaccine during chlorambucil therapy; consider vaccinating only after immunosuppression has resolved, as guided by specialist advice.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Chlorambucil and Dengue vaccine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Chlorambucil
Frequently asked questions
Can I take Chlorambucil with Dengue vaccine?
MediHelp rates the interaction as major. Chlorambucil and Dengue vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dengue vaccine is a live attenuated vaccine, and immunosuppression from chlorambucil can reduce the immune response and increase the risk of vaccine-related infection. Immunocompromised patients are generally not candidates for it.
How serious is the interaction between Chlorambucil and Dengue vaccine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live dengue vaccine during chlorambucil therapy; consider vaccinating only after immunosuppression has resolved, as guided by specialist advice.
What other medicines interact with Chlorambucil?
MediHelp also lists interactions of Chlorambucil with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Chlorambucil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
