Drug interactions
Chlorambucil + Olaparib
Severity: Moderate
Chlorambucil and Olaparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can suppress the bone marrow, and olaparib has been linked to anemia, neutropenia and rarely myelodysplastic syndrome. Together they may cause more severe or prolonged cytopenias.
What this interaction means in plain words
Chlorambucil and Olaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorambucil belongs to Oncology; Olaparib belongs to Oncology.
Why it happens
Additive myelosuppression from DNA-damaging agent and PARP inhibitor.
What to do
Monitor blood counts frequently and reduce doses or interrupt therapy for significant cytopenias.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorambucil
Other interactions of Olaparib
- Amiodarone + Olaparib Major
- Amobarbital + Olaparib Major
- Apalutamide + Olaparib Major
- Aprepitant + Olaparib Major
- Azathioprine + Olaparib Major
- Carbamazepine + Olaparib Major
Frequently asked questions
Can I take Chlorambucil with Olaparib?
MediHelp rates the interaction as moderate. Chlorambucil and Olaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can suppress the bone marrow, and olaparib has been linked to anemia, neutropenia and rarely myelodysplastic syndrome. Together they may cause more severe or prolonged cytopenias.
How serious is the interaction between Chlorambucil and Olaparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts frequently and reduce doses or interrupt therapy for significant cytopenias.
What other medicines interact with Chlorambucil?
MediHelp also lists interactions of Chlorambucil with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Chlorambucil page.
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