Drug interactions
Chlordiazepoxide + Cyproheptadine
Severity: Moderate
Chlordiazepoxide and Cyproheptadine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a benzodiazepine with a sedating antihistamine increases drowsiness, dizziness and psychomotor impairment. Older patients face a higher risk of falls and confusion.
What this interaction means in plain words
Chlordiazepoxide and Cyproheptadine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide belongs to Central Nervous System; Cyproheptadine belongs to Respiratory.
Why it happens
Additive CNS depression via H1 antagonism and GABA-A potentiation.
What to do
Use the lowest effective doses, avoid alcohol, and counsel against driving; avoid the combination in frail older adults where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Other interactions of Chlordiazepoxide
Frequently asked questions
Can I take Chlordiazepoxide with Cyproheptadine?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Cyproheptadine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a benzodiazepine with a sedating antihistamine increases drowsiness, dizziness and psychomotor impairment. Older patients face a higher risk of falls and confusion.
How serious is the interaction between Chlordiazepoxide and Cyproheptadine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses, avoid alcohol, and counsel against driving; avoid the combination in frail older adults where possible.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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