Drug interactions
Chlordiazepoxide + Dosulepin
Severity: Moderate
Chlordiazepoxide and Dosulepin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dosulepin is a sedating tricyclic antidepressant, and with a benzodiazepine it increases drowsiness and impairs psychomotor skills. Overdose of this combination is more dangerous than either drug alone.
What this interaction means in plain words
Chlordiazepoxide and Dosulepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide belongs to Central Nervous System; Dosulepin belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABA-A potentiation and tricyclic antihistaminic effects.
What to do
Use the lowest effective doses and review the benzodiazepine regularly. Monitor for oversedation, especially at initiation and in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Other interactions of Dosulepin
- Dosulepin + Isocarboxazid Contraindicated
- Dosulepin + Phenelzine Contraindicated
- Dosulepin + Thioridazine Contraindicated
- Dosulepin + Tranylcypromine Contraindicated
- Amitriptyline + Dosulepin Major
- Buprenorphine + Dosulepin Major
Frequently asked questions
Can I take Chlordiazepoxide with Dosulepin?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Dosulepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dosulepin is a sedating tricyclic antidepressant, and with a benzodiazepine it increases drowsiness and impairs psychomotor skills. Overdose of this combination is more dangerous than either drug alone.
How serious is the interaction between Chlordiazepoxide and Dosulepin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and review the benzodiazepine regularly. Monitor for oversedation, especially at initiation and in older patients.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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