Drug interactions
Chlordiazepoxide + Doxylamine
Severity: Moderate
Chlordiazepoxide and Doxylamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxylamine is a sedating antihistamine often found in sleep aids, and with a benzodiazepine it produces additive drowsiness and impaired alertness. Residual daytime sedation and falls are a particular concern in older adults.
What this interaction means in plain words
Chlordiazepoxide and Doxylamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide belongs to Central Nervous System; Doxylamine belongs to Respiratory.
Why it happens
Additive CNS depression via H1 receptor blockade and GABA-A potentiation.
What to do
Avoid using together for insomnia and counsel on driving and alcohol. Reduce doses in older or frail patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Other interactions of Doxylamine
Frequently asked questions
Can I take Chlordiazepoxide with Doxylamine?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Doxylamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxylamine is a sedating antihistamine often found in sleep aids, and with a benzodiazepine it produces additive drowsiness and impaired alertness. Residual daytime sedation and falls are a particular concern in older adults.
How serious is the interaction between Chlordiazepoxide and Doxylamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using together for insomnia and counsel on driving and alcohol. Reduce doses in older or frail patients.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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