Drug interactions
Chlordiazepoxide + Efavirenz
Severity: Minor
Chlordiazepoxide and Efavirenz: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlordiazepoxide is partly cleared by CYP3A4, so efavirenz may reduce its levels. Efavirenz CNS effects can also add to benzodiazepine sedation.
What this interaction means in plain words
Chlordiazepoxide and Efavirenz have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlordiazepoxide belongs to Central Nervous System; Efavirenz belongs to Anti Virals.
Why it happens
CYP3A4 induction by efavirenz increases chlordiazepoxide metabolism, plus additive CNS effects.
What to do
Monitor sedation and therapeutic response, adjusting the chlordiazepoxide dose as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Chlordiazepoxide
Frequently asked questions
Can I take Chlordiazepoxide with Efavirenz?
MediHelp rates the interaction as minor. Chlordiazepoxide and Efavirenz have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chlordiazepoxide is partly cleared by CYP3A4, so efavirenz may reduce its levels. Efavirenz CNS effects can also add to benzodiazepine sedation.
How serious is the interaction between Chlordiazepoxide and Efavirenz?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and therapeutic response, adjusting the chlordiazepoxide dose as needed.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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