Drug interactions
Chlordiazepoxide + Istradefylline
Severity: Minor
Chlordiazepoxide and Istradefylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Istradefylline at higher doses raises exposure to CYP3A4 substrates. Chlordiazepoxide is partly metabolized by CYP3A4, so levels and sedation could increase.
What this interaction means in plain words
Chlordiazepoxide and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlordiazepoxide belongs to Central Nervous System; Istradefylline belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by istradefylline at 40 mg/day decreases chlordiazepoxide metabolism.
What to do
Monitor for increased sedation if istradefylline 40 mg/day is used and consider lowering the chlordiazepoxide dose. No adjustment is generally needed at 20 mg/day.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlordiazepoxide
Other interactions of Istradefylline
Frequently asked questions
Can I take Chlordiazepoxide with Istradefylline?
MediHelp rates the interaction as minor. Chlordiazepoxide and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Istradefylline at higher doses raises exposure to CYP3A4 substrates. Chlordiazepoxide is partly metabolized by CYP3A4, so levels and sedation could increase.
How serious is the interaction between Chlordiazepoxide and Istradefylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased sedation if istradefylline 40 mg/day is used and consider lowering the chlordiazepoxide dose. No adjustment is generally needed at 20 mg/day.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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