Drug interactions
Chlordiazepoxide + Ivosidenib
Severity: Moderate
Chlordiazepoxide and Ivosidenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4 and may lower chlordiazepoxide concentrations. This may reduce anxiolytic or withdrawal-suppressing effects.
What this interaction means in plain words
Chlordiazepoxide and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide belongs to Central Nervous System; Ivosidenib belongs to Oncology.
Why it happens
Ivosidenib induces CYP3A4, increasing chlordiazepoxide metabolism.
What to do
Monitor for reduced efficacy, including anxiety or withdrawal symptoms, and adjust the dose accordingly. Consider an alternative benzodiazepine not dependent on CYP3A4.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Chlordiazepoxide with Ivosidenib?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib induces CYP3A4 and may lower chlordiazepoxide concentrations. This may reduce anxiolytic or withdrawal-suppressing effects.
How serious is the interaction between Chlordiazepoxide and Ivosidenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced efficacy, including anxiety or withdrawal symptoms, and adjust the dose accordingly. Consider an alternative benzodiazepine not dependent on CYP3A4.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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