Drug interactions
Chlordiazepoxide + Ketoconazole
Severity: Moderate
Chlordiazepoxide and Ketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole can increase chlordiazepoxide concentrations, leading to greater sedation, psychomotor impairment and respiratory depression, particularly in older adults or with other CNS depressants.
What this interaction means in plain words
Chlordiazepoxide and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide belongs to Central Nervous System; Ketoconazole belongs to Anti Fungals.
Why it happens
Ketoconazole inhibits CYP3A4-mediated oxidative metabolism of chlordiazepoxide.
What to do
Monitor for excess sedation and consider lowering the chlordiazepoxide dose. Consider a benzodiazepine cleared by glucuronidation, such as lorazepam, if long-term coadministration is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Chlordiazepoxide and Ketoconazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Other interactions of Chlordiazepoxide
Frequently asked questions
Can I take Chlordiazepoxide with Ketoconazole?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoconazole can increase chlordiazepoxide concentrations, leading to greater sedation, psychomotor impairment and respiratory depression, particularly in older adults or with other CNS depressants.
How serious is the interaction between Chlordiazepoxide and Ketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and consider lowering the chlordiazepoxide dose. Consider a benzodiazepine cleared by glucuronidation, such as lorazepam, if long-term coadministration is needed.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
