Drug interactions
Chlordiazepoxide + Larotrectinib
Severity: Minor
Chlordiazepoxide and Larotrectinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate that may weakly inhibit CYP3A4, so it could modestly raise chlordiazepoxide levels. The clinical impact is likely small.
What this interaction means in plain words
Chlordiazepoxide and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlordiazepoxide belongs to Central Nervous System; Larotrectinib belongs to Oncology.
Why it happens
Possible weak CYP3A4 inhibition reducing chlordiazepoxide metabolism.
What to do
Monitor for increased sedation and adjust the chlordiazepoxide dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlordiazepoxide
Other interactions of Larotrectinib
Frequently asked questions
Can I take Chlordiazepoxide with Larotrectinib?
MediHelp rates the interaction as minor. Chlordiazepoxide and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate that may weakly inhibit CYP3A4, so it could modestly raise chlordiazepoxide levels. The clinical impact is likely small.
How serious is the interaction between Chlordiazepoxide and Larotrectinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased sedation and adjust the chlordiazepoxide dose if needed.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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