Drug interactions
Chlordiazepoxide + Lorazepam
Severity: Moderate
Chlordiazepoxide and Lorazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using two benzodiazepines together offers little therapeutic benefit and increases sedation, respiratory depression and the risk of dependence. Overdose risk and falls in older adults are increased.
What this interaction means in plain words
Chlordiazepoxide and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide belongs to Central Nervous System; Lorazepam belongs to Central Nervous System.
Why it happens
Additive GABA-A receptor potentiation producing CNS depression.
What to do
Avoid routine duplication of benzodiazepines. If used deliberately, such as in alcohol withdrawal transitions, monitor sedation and respiratory status.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Other interactions of Lorazepam
Frequently asked questions
Can I take Chlordiazepoxide with Lorazepam?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Using two benzodiazepines together offers little therapeutic benefit and increases sedation, respiratory depression and the risk of dependence. Overdose risk and falls in older adults are increased.
How serious is the interaction between Chlordiazepoxide and Lorazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine duplication of benzodiazepines. If used deliberately, such as in alcohol withdrawal transitions, monitor sedation and respiratory status.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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