Drug interactions
Chlordiazepoxide + Lorlatinib
Severity: Moderate
Chlordiazepoxide and Lorlatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib induces CYP3A4 and may lower chlordiazepoxide concentrations, potentially reducing its anxiolytic or anticonvulsant effect. The effect has not been fully quantified for this specific drug.
What this interaction means in plain words
Chlordiazepoxide and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide belongs to Central Nervous System; Lorlatinib belongs to Oncology.
Why it happens
Induction of CYP3A4 by lorlatinib increases the metabolism of chlordiazepoxide.
What to do
Monitor for reduced benzodiazepine effect and withdrawal symptoms, and increase the dose if needed. Consider a benzodiazepine with less CYP3A4 dependence, such as lorazepam.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Chlordiazepoxide with Lorlatinib?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorlatinib induces CYP3A4 and may lower chlordiazepoxide concentrations, potentially reducing its anxiolytic or anticonvulsant effect. The effect has not been fully quantified for this specific drug.
How serious is the interaction between Chlordiazepoxide and Lorlatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced benzodiazepine effect and withdrawal symptoms, and increase the dose if needed. Consider a benzodiazepine with less CYP3A4 dependence, such as lorazepam.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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