Drug interactions
Chlordiazepoxide + Rifabutin
Severity: Minor
Chlordiazepoxide and Rifabutin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifabutin induces CYP3A4 and may lower chlordiazepoxide concentrations, potentially reducing its anxiolytic or anticonvulsant effect. Induction by rifabutin is weaker than with rifampicin, so the effect is generally modest.
What this interaction means in plain words
Chlordiazepoxide and Rifabutin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlordiazepoxide belongs to Central Nervous System; Rifabutin belongs to Anti Bacterial.
Why it happens
Induction of CYP3A4-mediated metabolism of chlordiazepoxide by rifabutin.
What to do
Monitor for reduced clinical response and adjust chlordiazepoxide dose if needed. Watch for rebound toxicity after rifabutin is stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlordiazepoxide
Other interactions of Rifabutin
- Cabotegravir + Rifabutin Contraindicated
- Lorlatinib + Rifabutin Contraindicated
- Rifabutin + Voriconazole Contraindicated
- Apixaban + Rifabutin Major
- Axitinib + Rifabutin Major
- Brexpiprazole + Rifabutin Major
Frequently asked questions
Can I take Chlordiazepoxide with Rifabutin?
MediHelp rates the interaction as minor. Chlordiazepoxide and Rifabutin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rifabutin induces CYP3A4 and may lower chlordiazepoxide concentrations, potentially reducing its anxiolytic or anticonvulsant effect. Induction by rifabutin is weaker than with rifampicin, so the effect is generally modest.
How serious is the interaction between Chlordiazepoxide and Rifabutin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced clinical response and adjust chlordiazepoxide dose if needed. Watch for rebound toxicity after rifabutin is stopped.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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