Drug interactions
Chlorpropamide + Choline magnesium trisalicylate
Severity: Moderate
Chlorpropamide and Choline magnesium trisalicylate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Choline magnesium trisalicylate delivers salicylate at anti-inflammatory doses and can potentiate chlorpropamide, leading to hypoglycemia.
What this interaction means in plain words
Chlorpropamide and Choline magnesium trisalicylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Salicylate displaces sulfonylureas from plasma proteins, may reduce their renal excretion and has intrinsic hypoglycemic effects at high doses.
What to do
Monitor blood glucose when starting, stopping or changing the salicylate dose and lower the chlorpropamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Chlorpropamide and Choline magnesium trisalicylate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Choline magnesium trisalicylate?
MediHelp rates the interaction as moderate. Chlorpropamide and Choline magnesium trisalicylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Choline magnesium trisalicylate delivers salicylate at anti-inflammatory doses and can potentiate chlorpropamide, leading to hypoglycemia.
How serious is the interaction between Chlorpropamide and Choline magnesium trisalicylate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting, stopping or changing the salicylate dose and lower the chlorpropamide dose if hypoglycemia occurs.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
