Drug interactions
Chlorpropamide + Ciprofibrate
Severity: Moderate
Chlorpropamide and Ciprofibrate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fibrates can improve insulin sensitivity and may enhance the effect of chlorpropamide, causing hypoglycemia. Patients with low serum albumin are at greater risk because more free drug is available.
What this interaction means in plain words
Chlorpropamide and Ciprofibrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ciprofibrate may add to glucose lowering through improved insulin sensitivity and could displace the highly protein-bound chlorpropamide from albumin.
What to do
Monitor blood glucose when ciprofibrate is started and reduce the chlorpropamide dose if hypoglycemia occurs, particularly in hypoalbuminemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Ciprofibrate?
MediHelp rates the interaction as moderate. Chlorpropamide and Ciprofibrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fibrates can improve insulin sensitivity and may enhance the effect of chlorpropamide, causing hypoglycemia. Patients with low serum albumin are at greater risk because more free drug is available.
How serious is the interaction between Chlorpropamide and Ciprofibrate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when ciprofibrate is started and reduce the chlorpropamide dose if hypoglycemia occurs, particularly in hypoalbuminemia.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
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