Drug interactions
Chlorpropamide + Clonidine
Severity: Moderate
Chlorpropamide and Clonidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clonidine can reduce the adrenergic warning symptoms of hypoglycemia such as tremor and palpitations. With chlorpropamide, which has a long half-life and a high hypoglycemia risk, this could delay recognition of low glucose.
What this interaction means in plain words
Chlorpropamide and Clonidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Clonidine belongs to Cardiovascular.
Why it happens
Central alpha-2 agonism reduces sympathetic outflow and catecholamine-mediated hypoglycemia symptoms.
What to do
Counsel the patient that sweating may remain but other warning signs may be dulled. Monitor blood glucose regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Clonidine?
MediHelp rates the interaction as moderate. Chlorpropamide and Clonidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clonidine can reduce the adrenergic warning symptoms of hypoglycemia such as tremor and palpitations. With chlorpropamide, which has a long half-life and a high hypoglycemia risk, this could delay recognition of low glucose.
How serious is the interaction between Chlorpropamide and Clonidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient that sweating may remain but other warning signs may be dulled. Monitor blood glucose regularly.
What other medicines interact with Clonidine?
MediHelp also lists interactions of Clonidine with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Clonidine page.
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