Drug interactions
Chlorpropamide + Cortisone
Severity: Moderate
Chlorpropamide and Cortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids raise blood glucose and can reduce the effectiveness of sulfonylureas. Glycemic control may worsen during treatment, and hypoglycemia can occur when the steroid is withdrawn.
What this interaction means in plain words
Chlorpropamide and Cortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism: increased gluconeogenesis and insulin resistance.
What to do
Monitor blood glucose during and after corticosteroid therapy. Increase the antidiabetic dose as needed, and reduce it again when the steroid is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Cortisone?
MediHelp rates the interaction as moderate. Chlorpropamide and Cortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids raise blood glucose and can reduce the effectiveness of sulfonylureas. Glycemic control may worsen during treatment, and hypoglycemia can occur when the steroid is withdrawn.
How serious is the interaction between Chlorpropamide and Cortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during and after corticosteroid therapy. Increase the antidiabetic dose as needed, and reduce it again when the steroid is stopped.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
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