Drug interactions
Chlorpropamide + Elvitegravir / cobicistat / emtricitabine / tenofovir df
Severity: Minor
Chlorpropamide and Elvitegravir / cobicistat / emtricitabine / tenofovir df: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpropamide is partly cleared by CYP2C9, and this combination product may modestly change its exposure. Cobicistat inhibits CYP3A and elvitegravir is a weak-to-moderate inducer of CYP2C9, so the net effect on glucose control is uncertain and may be a reduced hypoglycemic effect.
What this interaction means in plain words
Chlorpropamide and Elvitegravir / cobicistat / emtricitabine / tenofovir df have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible induction of CYP2C9 by elvitegravir altering chlorpropamide metabolism.
What to do
Monitor blood glucose after starting or stopping the antiretroviral regimen and titrate chlorpropamide as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates the interaction as minor. Chlorpropamide and Elvitegravir / cobicistat / emtricitabine / tenofovir df have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chlorpropamide is partly cleared by CYP2C9, and this combination product may modestly change its exposure. Cobicistat inhibits CYP3A and elvitegravir is a weak-to-moderate inducer of CYP2C9, so the net effect on glucose control is uncertain and may be a reduced hypoglycemic effect.
How serious is the interaction between Chlorpropamide and Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or stopping the antiretroviral regimen and titrate chlorpropamide as needed.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
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