Drug interactions
Chlorpropamide + Empagliflozin-linagliptin
Severity: Moderate
Chlorpropamide and Empagliflozin-linagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linagliptin and empagliflozin each add to the glucose-lowering effect of sulfonylureas, increasing the risk of hypoglycemia. Chlorpropamide is long-acting, so hypoglycemia may be prolonged, especially in older patients or those with renal impairment.
What this interaction means in plain words
Chlorpropamide and Empagliflozin-linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Empagliflozin-linagliptin belongs to Endocrine.
Why it happens
Additive glucose-lowering effects of insulin secretagogue with DPP-4 and SGLT2 inhibition.
What to do
Consider lowering the sulfonylurea dose when starting the combination and monitor blood glucose. Educate the patient about hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-linagliptin
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Empagliflozin-linagliptin?
MediHelp rates the interaction as moderate. Chlorpropamide and Empagliflozin-linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Linagliptin and empagliflozin each add to the glucose-lowering effect of sulfonylureas, increasing the risk of hypoglycemia. Chlorpropamide is long-acting, so hypoglycemia may be prolonged, especially in older patients or those with renal impairment.
How serious is the interaction between Chlorpropamide and Empagliflozin-linagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the sulfonylurea dose when starting the combination and monitor blood glucose. Educate the patient about hypoglycemia symptoms.
What other medicines interact with Empagliflozin-linagliptin?
MediHelp also lists interactions of Empagliflozin-linagliptin with, for example, Fosphenytoin, Rifampin, Rifapentine. The full list is on the Empagliflozin-linagliptin page.
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