Drug interactions
Chlorpropamide + Enalapril
Severity: Moderate
Chlorpropamide and Enalapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can potentiate the glucose-lowering effect of sulfonylureas and occasionally cause hypoglycemia. Chlorpropamide has a long half-life, so hypoglycemia can be prolonged.
What this interaction means in plain words
Chlorpropamide and Enalapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Enalapril belongs to Cardiovascular.
Why it happens
ACE inhibition may improve insulin sensitivity, adding to sulfonylurea hypoglycemic action.
What to do
Monitor blood glucose when enalapril is started or adjusted. Reduce the chlorpropamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Enalapril?
MediHelp rates the interaction as moderate. Chlorpropamide and Enalapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can potentiate the glucose-lowering effect of sulfonylureas and occasionally cause hypoglycemia. Chlorpropamide has a long half-life, so hypoglycemia can be prolonged.
How serious is the interaction between Chlorpropamide and Enalapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when enalapril is started or adjusted. Reduce the chlorpropamide dose if hypoglycemia occurs.
What other medicines interact with Enalapril?
MediHelp also lists interactions of Enalapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Enalapril page.
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