Drug interactions
Chlorpropamide + Fenoprofen
Severity: Moderate
Chlorpropamide and Fenoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may enhance the glucose-lowering effect of sulfonylureas such as chlorpropamide, increasing the risk of hypoglycemia. The effect is most relevant in older patients and those with renal impairment.
What this interaction means in plain words
Chlorpropamide and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Fenoprofen belongs to Musculoskeletal.
Why it happens
Probable displacement from plasma protein binding and reduced renal clearance of the sulfonylurea; the mechanism is not fully established.
What to do
Monitor blood glucose when starting or stopping the NSAID and reduce the sulfonylurea dose if hypoglycemia occurs. Counsel patients on hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Fenoprofen?
MediHelp rates the interaction as moderate. Chlorpropamide and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may enhance the glucose-lowering effect of sulfonylureas such as chlorpropamide, increasing the risk of hypoglycemia. The effect is most relevant in older patients and those with renal impairment.
How serious is the interaction between Chlorpropamide and Fenoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping the NSAID and reduce the sulfonylurea dose if hypoglycemia occurs. Counsel patients on hypoglycemia symptoms.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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