Drug interactions
Chlorpropamide + Fosamprenavir
Severity: Moderate
Chlorpropamide and Fosamprenavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosamprenavir, usually given with ritonavir, may alter chlorpropamide exposure, and protease inhibitors can induce insulin resistance and hyperglycemia. Glucose control may therefore become unpredictable.
What this interaction means in plain words
Chlorpropamide and Fosamprenavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ritonavir-related modulation of CYP2C9 and protease inhibitor-induced insulin resistance.
What to do
Monitor blood glucose after starting or changing therapy and adjust the chlorpropamide dose as needed. Use an alternative antidiabetic if control is unstable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Fosamprenavir?
MediHelp rates the interaction as moderate. Chlorpropamide and Fosamprenavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosamprenavir, usually given with ritonavir, may alter chlorpropamide exposure, and protease inhibitors can induce insulin resistance and hyperglycemia. Glucose control may therefore become unpredictable.
How serious is the interaction between Chlorpropamide and Fosamprenavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or changing therapy and adjust the chlorpropamide dose as needed. Use an alternative antidiabetic if control is unstable.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
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