Drug interactions
Chlorpropamide + Hydrochlorothiazide-olmesartan
Severity: Moderate
Chlorpropamide and Hydrochlorothiazide-olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide can raise blood glucose and reduce chlorpropamide efficacy. Thiazides may also contribute to hyponatremia, which chlorpropamide can cause through SIADH-like effects.
What this interaction means in plain words
Chlorpropamide and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Hydrochlorothiazide-olmesartan belongs to Cardiovascular.
Why it happens
Thiazide-induced impaired insulin secretion and sensitivity, plus additive effects on sodium handling.
What to do
Monitor blood glucose and serum sodium. Adjust antidiabetic therapy or choose a different sulfonylurea if problems occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Hydrochlorothiazide-olmesartan?
MediHelp rates the interaction as moderate. Chlorpropamide and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide can raise blood glucose and reduce chlorpropamide efficacy. Thiazides may also contribute to hyponatremia, which chlorpropamide can cause through SIADH-like effects.
How serious is the interaction between Chlorpropamide and Hydrochlorothiazide-olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and serum sodium. Adjust antidiabetic therapy or choose a different sulfonylurea if problems occur.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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