Drug interactions
Chlorpropamide + Indapamide
Severity: Moderate
Chlorpropamide and Indapamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indapamide can raise blood glucose and reduce the effectiveness of chlorpropamide. Thiazide-like diuretics may also contribute to hyponatremia, which chlorpropamide can cause through SIADH-like effects.
What this interaction means in plain words
Chlorpropamide and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Indapamide belongs to Cardiovascular.
Why it happens
Diuretic-related impairment of glucose tolerance and hypokalemia oppose sulfonylurea action, with additive risk of sodium depletion.
What to do
Monitor blood glucose and serum sodium after starting indapamide, and adjust chlorpropamide dose or consider a safer sulfonylurea.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indapamide
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Indapamide?
MediHelp rates the interaction as moderate. Chlorpropamide and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indapamide can raise blood glucose and reduce the effectiveness of chlorpropamide. Thiazide-like diuretics may also contribute to hyponatremia, which chlorpropamide can cause through SIADH-like effects.
How serious is the interaction between Chlorpropamide and Indapamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and serum sodium after starting indapamide, and adjust chlorpropamide dose or consider a safer sulfonylurea.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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