Drug interactions
Chlorpropamide + Insulin aspart-insulin aspart protamine
Severity: Moderate
Chlorpropamide and Insulin aspart-insulin aspart protamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpropamide with insulin gives additive glucose lowering, and its long half-life makes hypoglycemia prolonged and potentially severe, especially in the elderly or those with renal impairment.
What this interaction means in plain words
Chlorpropamide and Insulin aspart-insulin aspart protamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Insulin aspart-insulin aspart protamine belongs to Endocrine.
Why it happens
Additive pharmacodynamic effect of sulfonylurea-stimulated insulin secretion and exogenous insulin.
What to do
Monitor glucose closely and reduce the dose of either agent if hypoglycemia occurs. Consider a shorter-acting sulfonylurea in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin aspart-insulin aspart protamine
- Ethanol + Insulin aspart-insulin aspart protamine Major
- Insulin aspart-insulin aspart protamine + Pentamidine Major
- Insulin aspart-insulin aspart protamine + Pioglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Acarbose + Insulin aspart-insulin aspart protamine Moderate
- Albiglutide + Insulin aspart-insulin aspart protamine Moderate
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Insulin aspart-insulin aspart protamine?
MediHelp rates the interaction as moderate. Chlorpropamide and Insulin aspart-insulin aspart protamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpropamide with insulin gives additive glucose lowering, and its long half-life makes hypoglycemia prolonged and potentially severe, especially in the elderly or those with renal impairment.
How serious is the interaction between Chlorpropamide and Insulin aspart-insulin aspart protamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose closely and reduce the dose of either agent if hypoglycemia occurs. Consider a shorter-acting sulfonylurea in older patients.
What other medicines interact with Insulin aspart-insulin aspart protamine?
MediHelp also lists interactions of Insulin aspart-insulin aspart protamine with, for example, Ethanol, Pentamidine, Pioglitazone. The full list is on the Insulin aspart-insulin aspart protamine page.
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