Drug interactions
Chlorpropamide + Insulin aspart
Severity: Moderate
Chlorpropamide and Insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpropamide with insulin gives additive glucose lowering with a higher risk of hypoglycemia. Chlorpropamide has a long half-life, so hypoglycemia can be prolonged, particularly in older adults or renal impairment.
What this interaction means in plain words
Chlorpropamide and Insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Insulin aspart belongs to Endocrine.
Why it happens
Additive pharmacodynamic effect: chlorpropamide stimulates endogenous insulin secretion in addition to exogenous insulin.
What to do
Monitor blood glucose closely and reduce the dose of insulin or chlorpropamide if hypoglycemia occurs; consider a shorter-acting agent in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin aspart
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Insulin aspart?
MediHelp rates the interaction as moderate. Chlorpropamide and Insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpropamide with insulin gives additive glucose lowering with a higher risk of hypoglycemia. Chlorpropamide has a long half-life, so hypoglycemia can be prolonged, particularly in older adults or renal impairment.
How serious is the interaction between Chlorpropamide and Insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and reduce the dose of insulin or chlorpropamide if hypoglycemia occurs; consider a shorter-acting agent in older patients.
What other medicines interact with Insulin aspart?
MediHelp also lists interactions of Insulin aspart with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin aspart page.
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