Drug interactions
Chlorpropamide + Insulin detemir
Severity: Moderate
Chlorpropamide and Insulin detemir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpropamide with insulin leads to additive glucose lowering and a risk of severe, prolonged hypoglycemia. Chlorpropamide has a long half-life, so effects can persist.
What this interaction means in plain words
Chlorpropamide and Insulin detemir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Insulin detemir belongs to Endocrine.
Why it happens
Additive pharmacodynamic effect of sulfonylurea-induced insulin secretion and exogenous insulin.
What to do
Monitor glucose closely, especially in elderly or renally impaired patients, and reduce the doses of either drug if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin detemir
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Insulin detemir?
MediHelp rates the interaction as moderate. Chlorpropamide and Insulin detemir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpropamide with insulin leads to additive glucose lowering and a risk of severe, prolonged hypoglycemia. Chlorpropamide has a long half-life, so effects can persist.
How serious is the interaction between Chlorpropamide and Insulin detemir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose closely, especially in elderly or renally impaired patients, and reduce the doses of either drug if hypoglycemia occurs.
What other medicines interact with Insulin detemir?
MediHelp also lists interactions of Insulin detemir with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin detemir page.
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