Drug interactions
Chlorpropamide + Insulin lispro
Severity: Moderate
Chlorpropamide and Insulin lispro: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents lower blood glucose, so the combination increases hypoglycemia risk. Chlorpropamide has a long half-life, so hypoglycemia can be prolonged, particularly in older or renally impaired patients.
What this interaction means in plain words
Chlorpropamide and Insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Insulin lispro belongs to Endocrine.
Why it happens
Additive glucose lowering from exogenous insulin and sulfonylurea-stimulated insulin secretion.
What to do
Monitor blood glucose frequently and reduce the sulfonylurea or insulin dose if hypoglycemia occurs. Consider a shorter-acting alternative in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin lispro
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Insulin lispro?
MediHelp rates the interaction as moderate. Chlorpropamide and Insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents lower blood glucose, so the combination increases hypoglycemia risk. Chlorpropamide has a long half-life, so hypoglycemia can be prolonged, particularly in older or renally impaired patients.
How serious is the interaction between Chlorpropamide and Insulin lispro?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently and reduce the sulfonylurea or insulin dose if hypoglycemia occurs. Consider a shorter-acting alternative in older patients.
What other medicines interact with Insulin lispro?
MediHelp also lists interactions of Insulin lispro with, for example, Alogliptin-pioglitazone, Ethanol, Metreleptin. The full list is on the Insulin lispro page.
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