Drug interactions
Chlorpropamide + Insulin neutral human-insulin isophane protamine human
Severity: Moderate
Chlorpropamide and Insulin neutral human-insulin isophane protamine human: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining insulin with chlorpropamide increases the risk of hypoglycemia. Chlorpropamide has a very long half-life, so hypoglycemia can be prolonged, especially in older adults or those with renal impairment.
What this interaction means in plain words
Chlorpropamide and Insulin neutral human-insulin isophane protamine human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Insulin neutral human-insulin isophane protamine human belongs to Endocrine.
Why it happens
Additive hypoglycemic effect: insulin supplies glucose-lowering action while chlorpropamide stimulates endogenous insulin secretion.
What to do
Monitor glucose closely and reduce the insulin or sulfonylurea dose if hypoglycemia occurs. Prefer a shorter-acting agent in older or renally impaired patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin neutral human-insulin isophane protamine human
- Ethanol + Insulin neutral human-insulin isophane protamine human Major
- Insulin neutral human-insulin isophane protamine human + Pentamidine Major
- Insulin neutral human-insulin isophane protamine human + Rosiglitazone Major
- Acarbose + Insulin neutral human-insulin isophane protamine human Moderate
- Albiglutide + Insulin neutral human-insulin isophane protamine human Moderate
- Alogliptin + Insulin neutral human-insulin isophane protamine human Moderate
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Insulin neutral human-insulin isophane protamine human?
MediHelp rates the interaction as moderate. Chlorpropamide and Insulin neutral human-insulin isophane protamine human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining insulin with chlorpropamide increases the risk of hypoglycemia. Chlorpropamide has a very long half-life, so hypoglycemia can be prolonged, especially in older adults or those with renal impairment.
How serious is the interaction between Chlorpropamide and Insulin neutral human-insulin isophane protamine human?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose closely and reduce the insulin or sulfonylurea dose if hypoglycemia occurs. Prefer a shorter-acting agent in older or renally impaired patients.
What other medicines interact with Insulin neutral human-insulin isophane protamine human?
MediHelp also lists interactions of Insulin neutral human-insulin isophane protamine human with, for example, Ethanol, Pentamidine, Rosiglitazone. The full list is on the Insulin neutral human-insulin isophane protamine human page.
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