Drug interactions
Chlorpropamide + Ketorolac intranasal
Severity: Minor
Chlorpropamide and Ketorolac intranasal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs have been reported to potentiate sulfonylurea hypoglycemia, and ketorolac is highly protein bound. Intranasal dosing gives meaningful systemic exposure, though the clinical effect is probably modest.
What this interaction means in plain words
Chlorpropamide and Ketorolac intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible displacement from plasma protein binding and reduced renal prostaglandin-mediated clearance, though not firmly established.
What to do
Monitor blood glucose during short-term ketorolac use and watch renal function, as renal impairment prolongs chlorpropamide effect.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Ketorolac intranasal?
MediHelp rates the interaction as minor. Chlorpropamide and Ketorolac intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs have been reported to potentiate sulfonylurea hypoglycemia, and ketorolac is highly protein bound. Intranasal dosing gives meaningful systemic exposure, though the clinical effect is probably modest.
How serious is the interaction between Chlorpropamide and Ketorolac intranasal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during short-term ketorolac use and watch renal function, as renal impairment prolongs chlorpropamide effect.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
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