Drug interactions
Chlorpropamide + Ketorolac
Severity: Minor
Chlorpropamide and Ketorolac: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may enhance the glucose lowering effect of sulfonylureas, with a possible risk of hypoglycemia. Evidence for ketorolac specifically is limited.
What this interaction means in plain words
Chlorpropamide and Ketorolac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorpropamide belongs to Endocrine; Ketorolac belongs to Musculoskeletal.
Why it happens
Possible displacement from plasma protein binding and altered renal prostaglandin effects; the mechanism is not firmly established.
What to do
Monitor blood glucose when starting or stopping ketorolac and counsel the patient about hypoglycemia symptoms. Reduce the chlorpropamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Ketorolac?
MediHelp rates the interaction as minor. Chlorpropamide and Ketorolac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs may enhance the glucose lowering effect of sulfonylureas, with a possible risk of hypoglycemia. Evidence for ketorolac specifically is limited.
How serious is the interaction between Chlorpropamide and Ketorolac?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping ketorolac and counsel the patient about hypoglycemia symptoms. Reduce the chlorpropamide dose if hypoglycemia occurs.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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