Drug interactions
Chlorpropamide + Lumacaftor / ivacaftor
Severity: Moderate
Chlorpropamide and Lumacaftor / ivacaftor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumacaftor is an enzyme inducer and may lower exposure to CYP2C9 substrates. Chlorpropamide's glucose-lowering effect could be reduced.
What this interaction means in plain words
Chlorpropamide and Lumacaftor / ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Lumacaftor induces CYP2C9, increasing sulfonylurea metabolism.
What to do
Monitor blood glucose and HbA1c after starting or stopping lumacaftor/ivacaftor. Adjust chlorpropamide dose or switch agent if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Lumacaftor / ivacaftor?
MediHelp rates the interaction as moderate. Chlorpropamide and Lumacaftor / ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumacaftor is an enzyme inducer and may lower exposure to CYP2C9 substrates. Chlorpropamide's glucose-lowering effect could be reduced.
How serious is the interaction between Chlorpropamide and Lumacaftor / ivacaftor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or stopping lumacaftor/ivacaftor. Adjust chlorpropamide dose or switch agent if control worsens.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
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