Drug interactions
Chlorpropamide + Metformin-sitagliptin
Severity: Moderate
Chlorpropamide and Metformin-sitagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sitagliptin combined with a sulfonylurea such as chlorpropamide increases the risk of hypoglycemia. Chlorpropamide has a long half-life and is renally cleared, which prolongs hypoglycemia, particularly in older adults.
What this interaction means in plain words
Chlorpropamide and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Metformin-sitagliptin belongs to Endocrine.
Why it happens
Additive glucose lowering: sitagliptin enhances glucose-dependent insulin secretion on top of sulfonylurea-stimulated insulin release.
What to do
Consider reducing the chlorpropamide dose when adding sitagliptin and monitor for hypoglycemia, especially in elderly or renally impaired patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-sitagliptin
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Metformin-sitagliptin?
MediHelp rates the interaction as moderate. Chlorpropamide and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sitagliptin combined with a sulfonylurea such as chlorpropamide increases the risk of hypoglycemia. Chlorpropamide has a long half-life and is renally cleared, which prolongs hypoglycemia, particularly in older adults.
How serious is the interaction between Chlorpropamide and Metformin-sitagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the chlorpropamide dose when adding sitagliptin and monitor for hypoglycemia, especially in elderly or renally impaired patients.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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