Drug interactions
Chlorpropamide + Methyclothiazide
Severity: Moderate
Chlorpropamide and Methyclothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can raise blood glucose and reduce the effectiveness of sulfonylureas, which may worsen glycemic control. Thiazides may also compete for renal tubular secretion, and chlorpropamide can add to diuretic-related hyponatremia.
What this interaction means in plain words
Chlorpropamide and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thiazide-induced impairment of insulin secretion and glucose tolerance, with possible competition for renal tubular secretion of chlorpropamide.
What to do
Monitor blood glucose and serum sodium when the thiazide is started or the dose changes, and increase the antidiabetic regimen if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Chlorpropamide and Methyclothiazide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Methyclothiazide?
MediHelp rates the interaction as moderate. Chlorpropamide and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics can raise blood glucose and reduce the effectiveness of sulfonylureas, which may worsen glycemic control. Thiazides may also compete for renal tubular secretion, and chlorpropamide can add to diuretic-related hyponatremia.
How serious is the interaction between Chlorpropamide and Methyclothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and serum sodium when the thiazide is started or the dose changes, and increase the antidiabetic regimen if needed.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
