Drug interactions
Chlorpropamide + Methyltestosterone
Severity: Moderate
Chlorpropamide and Methyltestosterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgens can improve insulin sensitivity and lower blood glucose, potentially enhancing the effect of chlorpropamide and increasing hypoglycemia risk.
What this interaction means in plain words
Chlorpropamide and Methyltestosterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive glucose lowering through androgen-related increases in insulin sensitivity plus sulfonylurea insulin secretion.
What to do
Monitor blood glucose when methyltestosterone is started or stopped, and reduce the chlorpropamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Methyltestosterone?
MediHelp rates the interaction as moderate. Chlorpropamide and Methyltestosterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgens can improve insulin sensitivity and lower blood glucose, potentially enhancing the effect of chlorpropamide and increasing hypoglycemia risk.
How serious is the interaction between Chlorpropamide and Methyltestosterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when methyltestosterone is started or stopped, and reduce the chlorpropamide dose if hypoglycemia occurs.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
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