Drug interactions
Chlorpropamide + Miconazole vaginal
Severity: Moderate
Chlorpropamide and Miconazole vaginal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vaginally applied miconazole can be absorbed to a limited degree and may raise exposure to sulfonylureas. Reported cases with other miconazole forms involve enhanced glucose lowering and hypoglycemia. The risk with vaginal use is lower but is relevant in patients on long-acting chlorpropamide.
What this interaction means in plain words
Chlorpropamide and Miconazole vaginal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Miconazole inhibits CYP2C9, the main enzyme that metabolizes chlorpropamide, which can raise its plasma levels.
What to do
Monitor blood glucose and counsel the patient on hypoglycemia symptoms during and after the antifungal course. Reduce the chlorpropamide dose if glucose falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Miconazole vaginal?
MediHelp rates the interaction as moderate. Chlorpropamide and Miconazole vaginal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vaginally applied miconazole can be absorbed to a limited degree and may raise exposure to sulfonylureas. Reported cases with other miconazole forms involve enhanced glucose lowering and hypoglycemia. The risk with vaginal use is lower but is relevant in patients on long-acting chlorpropamide.
How serious is the interaction between Chlorpropamide and Miconazole vaginal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and counsel the patient on hypoglycemia symptoms during and after the antifungal course. Reduce the chlorpropamide dose if glucose falls.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
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