Drug interactions
Chlorpropamide + Oxymetholone
Severity: Moderate
Chlorpropamide and Oxymetholone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxymetholone, an anabolic steroid, can lower blood glucose and increase insulin sensitivity, potentially enhancing the effect of chlorpropamide and raising hypoglycemia risk.
What this interaction means in plain words
Chlorpropamide and Oxymetholone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive glucose lowering through increased insulin sensitivity plus sulfonylurea-induced insulin secretion.
What to do
Monitor blood glucose when oxymetholone is started or stopped, and lower the chlorpropamide dose if hypoglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Oxymetholone?
MediHelp rates the interaction as moderate. Chlorpropamide and Oxymetholone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxymetholone, an anabolic steroid, can lower blood glucose and increase insulin sensitivity, potentially enhancing the effect of chlorpropamide and raising hypoglycemia risk.
How serious is the interaction between Chlorpropamide and Oxymetholone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when oxymetholone is started or stopped, and lower the chlorpropamide dose if hypoglycemia develops.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
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