Drug interactions
Chlorpropamide + Parecoxib
Severity: Moderate
Chlorpropamide and Parecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs, including parecoxib's active metabolite valdecoxib, have been linked with enhanced sulfonylurea effect and hypoglycemia in some reports. Valdecoxib is also a CYP2C9 substrate and inhibitor, which could plausibly raise sulfonylurea levels. The effect is usually modest.
What this interaction means in plain words
Chlorpropamide and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible CYP2C9 competition or protein-binding displacement; the mechanism is not firmly established.
What to do
Monitor blood glucose during short-term use. Reduce the chlorpropamide dose if hypoglycemia emerges.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Parecoxib?
MediHelp rates the interaction as moderate. Chlorpropamide and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs, including parecoxib's active metabolite valdecoxib, have been linked with enhanced sulfonylurea effect and hypoglycemia in some reports. Valdecoxib is also a CYP2C9 substrate and inhibitor, which could plausibly raise sulfonylurea levels. The effect is usually modest.
How serious is the interaction between Chlorpropamide and Parecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during short-term use. Reduce the chlorpropamide dose if hypoglycemia emerges.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
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