Drug interactions
Chlorpropamide + Perindopril
Severity: Moderate
Chlorpropamide and Perindopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity, so adding perindopril to a sulfonylurea may lower blood glucose further. Hypoglycemia can be prolonged with chlorpropamide because of its long half-life.
What this interaction means in plain words
Chlorpropamide and Perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Perindopril belongs to Cardiovascular.
Why it happens
ACE inhibition may enhance insulin sensitivity and glucose uptake, adding to the insulin secretagogue effect of chlorpropamide.
What to do
Monitor blood glucose closely when starting or adjusting perindopril. Reduce the chlorpropamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perindopril
- Aliskiren + Perindopril Contraindicated
- Perindopril + Protein a column Contraindicated
- Perindopril + Sacubitril / valsartan Contraindicated
- Perindopril + Sacubitril-valsartan Contraindicated
- Amifostine + Perindopril Major
- Amiloride + Perindopril Major
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Perindopril?
MediHelp rates the interaction as moderate. Chlorpropamide and Perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can improve insulin sensitivity, so adding perindopril to a sulfonylurea may lower blood glucose further. Hypoglycemia can be prolonged with chlorpropamide because of its long half-life.
How serious is the interaction between Chlorpropamide and Perindopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting or adjusting perindopril. Reduce the chlorpropamide dose if hypoglycemia occurs.
What other medicines interact with Perindopril?
MediHelp also lists interactions of Perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Perindopril page.
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