Drug interactions
Chlorpropamide + Quinapril
Severity: Moderate
Chlorpropamide and Quinapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity and have been associated with hypoglycemia in patients on sulfonylureas or insulin. The risk is highest early in therapy and in those with renal impairment.
What this interaction means in plain words
Chlorpropamide and Quinapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effect through enhanced insulin sensitivity and possibly increased bradykinin.
What to do
Monitor blood glucose when starting or increasing quinapril. Reduce the chlorpropamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Quinapril?
MediHelp rates the interaction as moderate. Chlorpropamide and Quinapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can improve insulin sensitivity and have been associated with hypoglycemia in patients on sulfonylureas or insulin. The risk is highest early in therapy and in those with renal impairment.
How serious is the interaction between Chlorpropamide and Quinapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or increasing quinapril. Reduce the chlorpropamide dose if hypoglycemia occurs.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
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