Drug interactions
Chlorpropamide + Salsalate
Severity: Moderate
Chlorpropamide and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is hydrolyzed to salicylic acid, which can lower glucose and potentiate sulfonylureas. Hypoglycemia is the main concern, and it may be prolonged with chlorpropamide.
What this interaction means in plain words
Chlorpropamide and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive glucose-lowering by salicylate with possible protein-binding displacement.
What to do
Monitor blood glucose after starting or changing salsalate. Lower the chlorpropamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Salsalate?
MediHelp rates the interaction as moderate. Chlorpropamide and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate is hydrolyzed to salicylic acid, which can lower glucose and potentiate sulfonylureas. Hypoglycemia is the main concern, and it may be prolonged with chlorpropamide.
How serious is the interaction between Chlorpropamide and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or changing salsalate. Lower the chlorpropamide dose if hypoglycemia occurs.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
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