Drug interactions
Chlorpropamide + Somapacitan
Severity: Moderate
Chlorpropamide and Somapacitan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone analogs can reduce insulin sensitivity and raise blood glucose. In a patient taking chlorpropamide, glycemic control may deteriorate after somapacitan is started or the dose is increased.
What this interaction means in plain words
Chlorpropamide and Somapacitan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Somapacitan belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: growth hormone induces insulin resistance, opposing the glucose-lowering effect of the sulfonylurea.
What to do
Monitor blood glucose and HbA1c after starting or adjusting somapacitan. Increase the antidiabetic dose or add therapy if glycemic control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpropamide
Other interactions of Somapacitan
- Alogliptin-metformin + Somapacitan Moderate
- Alogliptin-pioglitazone + Somapacitan Moderate
- Alogliptin + Somapacitan Moderate
- Bazedoxifene-conjugated estrogens + Somapacitan Moderate
- Canagliflozin-metformin + Somapacitan Moderate
- Cyclosporin + Somapacitan Moderate
Frequently asked questions
Can I take Chlorpropamide with Somapacitan?
MediHelp rates the interaction as moderate. Chlorpropamide and Somapacitan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Growth hormone analogs can reduce insulin sensitivity and raise blood glucose. In a patient taking chlorpropamide, glycemic control may deteriorate after somapacitan is started or the dose is increased.
How serious is the interaction between Chlorpropamide and Somapacitan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or adjusting somapacitan. Increase the antidiabetic dose or add therapy if glycemic control worsens.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
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